Originals
Annett Bennewitz, Manfred Prinz, Uwe Wollina
Photodynamic therapy to improve wound healing in acute and chronic wounds: Tricyclic dye combined with low level 810 nm diode laser irradiation
Keywords | Summary | Correspondence | References
Keywords
Chronic leg ulcers, diode laser, methylen blue, split skin harvesting sites, wound healing
Schlüsselworte
Summary
Background: Antimicrobial photodynamic therapy is widely accepted in
dentistry. We investigated the possible benefit of antimicrobial phototherapy
in a pilot study for chronic and acute wounds.
Patients and methods: Sixteen patients with chronic leg ulcers and/or
split skin harvesting site participated. Wounds were treated either by
a-thermic 810 nm diode laser after topical application of methylen
blue solution (BLUEbact) or laser alone. Wounds were scored by the
Wollina Wound Score. Regular microbial swabs were taken for semiquantitative
evaluation.
Results: Of 19 leg ulcers, 15 were treated by photodynamic therapy with
BLUEbact, 3 only by diode laser. Of 6 split skin harvesting sites, 5 were
treated by photodynamic therapy and one by laser only. Fluence per session
was 60 J/cm2. Eleven leg ulcers received at least 3 treatments. Split
harvesting sites received 3 to 5 sessions of treatment. In 8 of 13 leg ulcers
partial improvement was seen by photodynamic therapy (62 %). Five of 6
split skin harvesting sites (83 %) responded well, most with a complete
healing. Exudation was stopped early and inflammation was seen less
pronounced as in untreated wounds. Although some ulcers showed a
reduction in microbiological colonization evaluation of all leg ulcers did
not argue for a significant antimicrobial effect of photodynamic therapy.
Of the 3 leg ulcers treated by laser alone, 2 had not responded.
Conclusions: Photodynamic therapy of leg ulcers and split skin harvesting
sites with a-thermic diode laser reduces clinical signs of inflammation
and seems to improve re-epithelialization. Further studies are necessary.
Zusammenfassung
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Address of Correspondence
Prof. Dr. Uwe Wollina
Department of Dermatology and Allergology
Academic Teaching Hospital Dresden-Friedrichstadt
D-01067 Dresden, Germany
E-mail: wollina-uw@khdf.de
Conflict of Interests
None
References
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